Q: "Find me any association or case report of intracranial aneurysms with ADPKD IFT-140"
Oddly, both OpenEvidence and Doximity answer incorrectly. There are multiple cases of this reported. Gemini and Perplexity get it right.
OpenEvidence (Snow, the newest model): "No published case report or cohort study has specifically documented an intracranial aneurysm (ICA) in a patient with monoallelic IFT140-associated ADPKD."
Doximity (Thinking): "Based on comprehensive searches of the medical literature, there are currently no published case reports or established associations linking IFT-140 mutations specifically to intracranial aneurysms."
Gemini (3.1 Pro, Deep Think): "Yes, there is a documented association between intracranial aneurysms (ICAs) and Autosomal Dominant Polycystic Kidney Disease (ADPKD) caused by monoallelic mutations in the IFT140 gene."
Perplexity (Deep Research): "Yes — there is published evidence linking IFT140-related ADPKD to intracranial aneurysms (IAs), though the data are limited to small case series, and authors uniformly describe the association as unconfirmed/preliminary rather than established."
