over my med body! » Physiology of Breaking The Seal
Okay medical blogosphere, let’s figure this one out (comments are open!). Is there a physiologic mechanism to “breaking the seal,” or is it just a drinking myth? (Breaking the seal, if you’re not familiar with the term, refers to the idea that if you’re out drinking, once you start peeing, then you’re going to have to go urinate every 10-20 minutes after that. “Don’t break the seal!” means don’t start peeing, ’cause then you’ll never stop!)
I'm not buying it. It probably has to do with parasympathetic activity overcoming sympathetic tone mediated renin release. The reduced renin release results in lower ang II and aldo resulting in less volume retention.
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